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Women in their 60s and beyond experience thinning of the skin (fragile dermis, age spots, and bruises become more noticeable) with delayed wound healing, along with reduced ability to sense touch, pressure, temperature, etc

What really causes acid reflux is, in most cases, lower esophageal sphincter (LES) dysfunction

Ann Neurol 32: S10S15

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The exact cause of IBS is not fully understood, but it is believed to involve a combination of gut motility issues, inflammation, and sensitivity to various triggers